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Diphenoxylate

O  General Information and Indications:

Diphenoxylate and atropine is used to control diarrhea.

O  Information For Users:

Diphenoxylate and atropine comes as a tablet and liquid to take by mouth. It is usually taken as needed up to four times a day. Follow the directions on your prescription label, ask your doctor or pharmacist If you have any questions.

The liquid comes in a container with a special dropper. Use the dropper to measure the exact dose carefully. Ask your pharmacist if you have questions about how to measure a dose.

Diphenoxylate can be habit forming. Do not take a larger dose, take it more often, or for a longer period than your doctor tells you to. Stopping the medicine suddenly after taking it for a long time may cause withdrawal. Symptoms of withdrawal include muscle cramps, stomach cramps, unusual sweating, upset stomach and vomiting, and shaking or trembling.

O  Special precautions:

o Inform your doctor or pharmacist if you have allergy to diphenoxylate, atropine, or any other medications.
o Inform your doctor and pharmacist what prescription and nonprescription medications you are taking, especially MAO inhibitors [phenelzine (Nardil) and tranylcypromine (Parnate)], muscle relaxants, narcotic cough or pain relievers, sleeping pills, tranquilizers, and vitamins.
o inform your doctor if you are breast-feeding chronic lung disease, ulcerative colitis, or liver disease or a history of alcohol abuse.
o Inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking diphenoxylate and atropine, call your doctor.
o before having surgery, including dental surgery, Inform your doctor or dentist that you are taking this medicine.
o you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
o remember that alcohol can add to the drowsiness caused by this drug.


O  Possible Adverse Effects:

Though adverse effects of diphenoxylate and atropine are not common, they could occur. To avoid thirst and dry mouth, drink a lot of fluids, chew gum, or suck sugarless hard candies.

If you have any of the following symptoms, call your doctor without delay:

o severe upset stomach and vomiting
o severe stomach pain
o bloating
o severe drowsiness
o palpitations
o swelling
o rash
o loss of appetite (anorexia)
o dryness of the skin, nose, or mouth,
o difficulty breathing
o convulsions

O  Brand Name(s):

o Lofene®
o Logen®
o Lomenate®
o Lomotil®
o Lonox®
o Lo-Trol®

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