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Hydroxychloroquine

O  General Information and Indications:

Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments.

O  Information For Users:

Hydroxychloroquine comes as a tablet to take by mouth. For prevention of malaria in adults, two tablets are usually taken once a week on exactly the same day of each week. The first dose is taken 1-2 weeks before traveling to an area where malaria is common, and then doses are continued for 8 weeks after exposure. For treatment of acute attacks of malaria in adults, four tablets are usually taken right away, followed by two tablets 6-8 hours later and then two tablets on each of the next 2 days.

For prevention or treatment of malaria in infants and children, the amount of hydroxychloroquine is based on the child's weight. Your doctor will calculate this amount and tell you how much hydroxychloroquine your child should receive.

For lupus erythematosus, one or two tablets are usually taken once or twice daily. For rheumatoid arthritis, one to three tablets are usually taken once a day.

Hydroxychloroquine can be taken with a glass of milk or a meal to decrease stomach upset. Follow the directions on your prescription label, ask your doctor or pharmacist If you have any questions. Take hydroxychloroquine exactly as directed. Do not take more or less of it or take it more often than prescribed by your health care provider.

If you are taking hydroxychloroquine for symptoms of rheumatoid arthritis, your symptoms should improve within 6 months. If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor. Once you and your doctor are sure the drug works for you, Do not discontinue taking hydroxychloroquine without informing your doctor. Symptoms of rheumatoid arthritis will return if you stop taking hydroxychloroquine.
Other uses for this medicine

Hydroxychloroquine is used occasionally to treat porphyria cutanea tarda. Talk to your doctor about the possible risks of using this medication.

O  Special precautions:

o Inform your doctor or pharmacist if you have allergy to hydroxychloroquine, chloroquine (Aralen), primaquine, or any other medications.
o Inform your doctor and pharmacist what prescription and nonprescription drugs you are taking, especially acetaminophen (Tylenol, others), digoxin (Lanoxin), iron-containing medications (including multivitamins), isoniazid (Nydrazid), methotrexate (Rheumatrex), niacin, rifampin (Rifadin, Rimactane), and vitamins and herbal products.
o inform your doctor if you are breast-feeding liver disease, psoriasis, porphyria or other blood disorders, G-6-PD deficiency, dermatitis (skin inflammations), or if you drink large amounts of alcohol.
o Inform your doctor if you have ever had vision changes while taking hydroxychloroquine, chloroquine (Aralen), or primaquine.
o Inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking hydroxychloroquine, call your doctor.

If you are taking hydroxychloroquine for a long period of time, your doctor will recommend frequent eye exams. It is very important that you keep these appointments. Hydroxychloroquine can cause serious vision problems. If you experience any changes in vision, stop taking hydroxychloroquine and call your doctor without delay.


O  Possible Adverse Effects:

Though adverse effects of hydroxychloroquine are not common, they could occur.Inform your doctor if any of the following symptoms are severe or do not go away:

o headache
o dizziness
o loss of appetite (anorexia)
o upset stomach
o diarrhea
o stomach pain
o vomiting
o skin rash

If you have any of the following symptoms, call your doctor without delay:

o reading or seeing difficulties (words, letters, or parts of objects missing)
o sensitivity to light
o blurred distance vision
o seeing light flashes or streaks
o difficulty hearing
o ringing in the ears (Tinnitus)
o muscle weakness
o bleeding or bruising of the skin
o bleaching or loss of hair
o mood or mental changes
o irregular heartbeat
o drowsiness
o convulsions

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