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Indomethacin

O  General Information and Indications:

Indomethacin is used to relieve the pain, tenderness, inflammation (swelling), and stiffness caused by gout, arthritis, and other inflammatory conditions.

O  Information For Users:

Indomethacin comes as a regular capsule, extended-release (long-acting) capsule, and a liquid to take by mouth and suppositories to be used rectally. Indomethacin capsules, liquid, and suppositories usually are taken two to four times a day; extended-release capsules are taken one or two times a day. Follow the directions on your prescription label, ask your doctor or pharmacist If you have any questions. Take indomethacin exactly as directed. Do not take more or less of it or take it more often than prescribed by your health care provider.

Extended-release capsules should be swallowed whole; do not open them to mix with food or beverages.

Shake the oral liquid well before each use.

To insert a suppository into the rectum, follow these steps:

o Remove the wrapper.
o Dip the tip of the suppository in water.
o Lie down on your left side and raise your right knee to your chest. (A left-handed person should lie on the right side and raise the left knee.)
o Using your finger, insert the suppository into the rectum, about 1/2 to 1 inch in infants and children and 1 inch in adults. Hold it in place for a few moments.
o Stand up after about 15 minutes. Wash your hands thoroughly and resume your normal activities.

O  Special precautions:

o Inform your doctor or pharmacist if you have allergy to indomethacin, aspirin or other medications for pain or arthritis, or any other medications.
o Inform your doctor and pharmacist what prescription and nonprescription medications you are taking, especially anticoagulants ('blood thinners') such as warfarin (Coumadin), aspirin, atenolol (Tenormin), carteolol (Cartrol), cyclosporine (Neoral, Sandimmune), digoxin (Lanoxin), diuretics ('water pills'), labetalol (Normodyne, Trandate), lithium (Eskalith, Lithobid), medications for arthritis or diabetes, methotrexate, metoprolol (Lopressor), nadolol (Corgard), phenylpropanolamine, phenytoin (Dilantin), probenecid (Benemid), and vitamins.
o inform your doctor if you are breast-feeding liver, heart, or kidney disease; high blood pressure; any stomach problems; any other gastrointestinal disease; epilepsy; Parkinson's disease; depression; or mental illness.
o Inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking indomethacin, call your doctor.
o if you are having surgery, including dental surgery, Inform your doctor or dentist that you are taking indomethacin.
o you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
o remember that alcohol can add to the drowsiness caused by this drug. Do not drink alcohol while taking this medication.

Indomethacin may cause an upset stomach. Take indomethacin with food or milk.


O  Possible Adverse Effects:

Though adverse effects of indomethacin are not common, they could occur. Inform your doctor if any of the following symptoms are severe or do not go away:

o headache
o dizziness
o nervousness
o upset stomach
o stomach cramps or pain
o vomiting
o diarrhea
o constipation

If you have any of the following symptoms, call your doctor without delay:

o blood in the vomit (Hematemesis)
o bloody diarrhea or black, tarry stools
o ringing in the ears
o swelling of the hands, feet, ankles, or lower legs
o skin rash
o itching

O  Brand Name(s):

o Indocin®
o Indocin® I.V.


 

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