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Hyzaar ( losartan + hydrochlorothiazide )

General Information and Indications:

The combination of losartan and hydrochlorothiazide, Hyzaar, is used to treat high blood pressure. Losartan is in a class of medications called angiotensin II receptor antagonists. It works by blocking the action of certain chemicals that tighten the blood vessels, so blood flows more smoothly. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.

Information For Users:

The combination of losartan and hydrochlorothiazide comes as a tablet to take by mouth. It is usually taken once a day with or without food. To help you remember to take losartan and hydrochlorothiazide, take it around the same time every day. Follow the directions on your prescription label, ask your doctor or pharmacist If you have any questions. Take losartan and hydrochlorothiazide exactly as directed. Do not take more or less of it or take it more often than prescribed by your health care provider.

Losartan and hydrochlorothiazide controls high blood pressure but does not cure it. Continue taking losartan and hydrochlorothiazide even if you feel well. Do not discontinue taking losartan and hydrochlorothiazide without informing your doctor.
Other uses for this medicine

Special precautions:

o Inform your doctor or pharmacist if you have allergy to losartan (Cozaar), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), sulfa drugs, or any other medications.
o Inform your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as indomethacin (Indocin); cholestyramine (Questran); colestipol (Colestid); insulin or oral medications for diabetes; lithium (Eskalith, Lithobid); narcotic pain medications; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); other diuretics; other medications for high blood pressure; phenobarbital (Luminal, Solfoton); and potassium supplements. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
o inform your doctor if you are breast-feeding gout; lupus; asthma; allergies; heart failure; diabetes; high blood levels of cholesterol or other fats (triglycerides); or liver or kidney disease.
o Inform your doctor if you plan to become pregnant or are breast-feeding.
o if you are having surgery, including dental surgery, Inform your doctor or dentist that you are taking losartan and hydrochlorothiazide.
o ask your doctor about the safe use of alcoholic beverages while you are taking losartan and hydrochlorothiazide. Alcohol can make the side effects from losartan and hydrochlorothiazide worse.
o you should know that diarrhea, vomiting, not drinking enough fluids, and sweating a lot can cause a drop in blood pressure, which may cause lightheadedness and fainting.

Possible Adverse Effects:

Losartan and hydrochlorothiazide may cause adverse effects. Inform your doctor if any of the following symptoms are severe or do not go away:

o dizziness
o runny nose
o sore throat
o back pain

Some adverse effects could be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor without delay:

o swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
o hoarseness
o difficulty swallowing or breathing
o hives (Urticaria)
o dry mouth
o thirst
o weakness
o drowsiness
o restlessness
o confusion
o seizures
o muscle pains or cramps
o infrequent urination
o upset stomach
o vomiting
o lightheadedness
o fainting
o rapid, pounding, or irregular heartbeat

Possible Symptoms of Overdose:

o dizziness
o lightheadedness
o fainting
o rapid or pounding heartbeat

Brand Name(s):

o Hyzaar®